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Identification of caffeine and its metabolites in human urine extracts by electron impact ionization tandem mass spectrometry
Author(s) -
Liguori A.,
Mascaro P.,
Porcelli B.,
Sindona G.,
Uccella N.
Publication year - 1991
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210260613
Subject(s) - theobromine , paraxanthine , chemistry , tandem mass spectrometry , caffeine , mass spectrometry , urine , chromatography , electron ionization , metabolite , metabolomics , tandem , ionization , biochemistry , biology , organic chemistry , enzyme , ion , microsome , materials science , endocrinology , cyp1a2 , composite material
Abstract Electron impact ionized purine bases such as caffeine and its metabolites (theopbylline, theobromine, paraxanthine, 1‐methylxanthine, 3‐metnybumthine and 7‐methyIxanthine) were characterized by tandem mass spectrometry. The direct analysts of human urinary extracts by tandem mass spectrometry allows the unambiguous identification of caffeine and its metabolites present simultaneously in the urine.