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Comparison of mass spectrometric methods for studying thermally labile compounds: Rifapentine
Author(s) -
Vékey Kàroly,
Edwards Duncan M. F.,
Zerilli Luigi F.,
Màk Marianna,
Tamàs Jòzsef,
Raverdino Vittorio,
Selva Antonio
Publication year - 1990
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210250907
Subject(s) - fragmentation (computing) , ionization , ion , mass spectrometry , chemistry , fast atom bombardment , rifapentine , evaporation , mass spectrum , ion source , analytical chemistry (journal) , ion beam , chromatography , organic chemistry , physics , mycobacterium tuberculosis , tuberculosis , medicine , pathology , computer science , latent tuberculosis , thermodynamics , operating system
Results of 16 different mass spectrometric ionization and sample‐introduction methods are compared for the case of a thermally very labile antibiotic, rifapentine. These suggest that extensive thermal decomposition occurs during evaporation when the sample can come into contact with hot metal parts, usually the source housing. The intensity of the molecular ion and the extent of fragmentation depend on various parameters, such as the ionization process, positive or negative‐ion detection and the type of sample introduction. The most informative methods for rifapentine seem to be ‘in‐beam’ electron impact, negative ionization with particle beam and direct liquid introduction interfaces and positive‐ and negative‐ion fast atom bombardment.