Premium
Negative ion liquid secondary ion mass spectrometry of carbamate‐linked oligodeoxynucleosides. II
Author(s) -
Laramée James A.,
Arbogast Brian,
Stirchak Eugene P.,
Weller Dwight D.,
Deinzer Max L.
Publication year - 1990
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210250408
Subject(s) - chemistry , carbamate , fragmentation (computing) , mass spectrometry , ion , electron ionization , polyatomic ion , molecule , amide , fast atom bombardment , analytical chemistry (journal) , chromatography , organic chemistry , ionization , computer science , operating system
Carbamate‐linked Oligodeoxynucleosides, in which the backbone consists of carbamate and N ‐methylcarbamate linkages, have been analyzed by negative ion liquid secondary ion mass spectrometry. Bidirectional sequence‐determining fragmentations are postulated to occur from a common radical anion intermediate that is produced by capture of an ionizing electron by the neutral sample molecule. Fragmentation reactions appear to be related to whether a proton or methyl group is present on the amide nitrogen.