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Natural isotopes as a tool in the elucidation of elemental composition and fragmentation pathways by tandem mass spectrometry
Author(s) -
de Hoffman Edmond,
Auriel Michel
Publication year - 1989
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210240907
Subject(s) - chemistry , fragmentation (computing) , mass spectrometry , tandem mass spectrometry , natural abundance , isotope , ion , tandem , collision induced dissociation , mass spectrum , polyatomic ion , elemental analysis , analytical chemistry (journal) , inorganic chemistry , organic chemistry , chromatography , materials science , quantum mechanics , computer science , composite material , operating system , physics
Comparison of daughter spectra obtained by tandem quadrupole mass Spectrometry from ions selected from an isotopic cluster of the same elemental composition can be efficiently used to find out the elemental composition of a fragment. This even applies with ions of high mass and with low abundance isotopes such as 18 O. By this method, loss of CO and HCO˙ from the phenol molecular ion is confirmed and the absence of CO loss from the p‐tert ‐butyl‐pbenol molecular ion is made obvious. Limitations of the method are discussed in the case of a bicyclic imidazolidinone.