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Mass spectrometry of pancuronium bromide and related quaternary ammonium steroids using the moving belt LC/MS interface
Author(s) -
Baker Timothy R.,
Vouros Paul,
Martyn Jeevendra A. J.
Publication year - 1989
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210240904
Subject(s) - chemistry , fast atom bombardment , fragmentation (computing) , pancuronium bromide , mass spectrometry , bromide , deuterium , ammonium , ammonium bromide , ionization , chromatography , analytical chemistry (journal) , inorganic chemistry , organic chemistry , anesthesia , ion , computer science , atomic physics , medicine , pulmonary surfactant , biochemistry , physics , operating system
Pancuronium and vecuronium are members of a series of quaternary ammonium steroids used as neuromuscular blocking agents in anesthesiology. In this study the mass spectrometric properties of these bromide salts are examined and spectral features which permit their differentiation are evaluated. The relative merits of chemical ionization and fast atom bombardment using the moving belt liquid chromatography/mass spectrometry interface have been investigated. Fragmentation pathways for both ionization methods were determined with deuterium labeling and linked‐scan techniques. Cleaner spectra can be obtained via the matrix‐free belt introduction system as compared to conventional fast atom bombardment.