Kinetics of acrylamide/glutathione binding by fast atom bombardment and thermospray mass spectrometry | Zendy

Harrison M. E. | Zendy; Baldwin M. A. | Zendy

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Kinetics of acrylamide/glutathione binding by fast atom bombardment and thermospray mass spectrometry

Author(s) -

Harrison M. E.,

Baldwin M. A.

Publication year - 1989

Publication title -

organic mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0030-493X

DOI - 10.1002/oms.1210240828

Subject(s) - thermospray , chemistry , mass spectrometry , fast atom bombardment , kinetics , acrylamide , reaction rate constant , glutathione , cysteine , analytical chemistry (journal) , chromatography , organic chemistry , tandem mass spectrometry , selected reaction monitoring , enzyme , physics , quantum mechanics , polymer , copolymer

The kinetics of the binding of the neurotoxin acrylamide to the cysteine residue of glutathione has been studied. At 37 °C and pH 7.3 the second order rate constant has been determined to be 0.72 ± 0.06 mol −1 dm 3 min −1 by thermospray mass spectrometry. The critical energy at pH 11.5 measured over the temperature range 10–37°C by fast atom bombardment mass spectrometry was measured as 24.6 kJ mol −1 .

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