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The use of signal averaging techniques for the quantitation and mass measurement of high molecular weight compounds using fast atom bombardment mass spectrometry
Author(s) -
Grotjahn L.,
Taylor L. C. E.
Publication year - 1985
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210200214
Subject(s) - mass spectrometry , chemistry , signal (programming language) , fast atom bombardment , analytical chemistry (journal) , chromatography , computer science , programming language
The measurement and recording of peak signals at high mass is often difficult and susceptible to a large degree of error. Signal averaging of repetitive scans has been used to improve detection limits and aid nominal mass assignment by peak matching. This is illustrated using glucagon as the reference material to determine the mass of the [MH] + peak in the molecular ion cluster of Vasoactive Intestinal Peptide, and caesium iodide as reference to mass‐measure a 13‐unit oligonucleotide.