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Isotopic distribution of the polyhaloorganics formed from the halogenation of haloorganics with isotopically enriched halogens
Author(s) -
Tanner D. D.,
Ruo T. S.,
Kosugi J.
Publication year - 1983
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210181103
Subject(s) - halogen , halogenation , chemistry , mass spectrometry , bromine , isotopic labeling , computational chemistry , organic chemistry , chromatography , alkyl
Halogenation reactions, both brominations and chlorinations, of haloorganics lead to di‐ or often polyhalogenated products. A major mechanistic question concerning these reactions always remains unanswered; whether they proceed by direct substitution or whether they proceed by a process involving an elimination‐readdition sequence. The question can be answered by carrying out the reactions using isotopically enriched halogen. A method of analysis has been devised, using high resolution mass spectrometry, which determines the isotopic distribution in each of the individual halogen atoms. The details of this procedure are presented in this report and examples of its use from several mechanistic investigations are presented.