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Application of a secondary ion mass spectrometer as a detector in liquid chromatography
Author(s) -
Benninghoven A.,
Eicke A.,
Junack M.,
Sichtermann W.,
Krizek J.,
Peters H.
Publication year - 1980
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210150907
Subject(s) - mass spectrometry , quadrupole mass analyzer , chemistry , chromatography , hybrid mass spectrometer , spectrometer , analytical chemistry (journal) , secondary ion mass spectrometry , liquid chromatography–mass spectrometry , triple quadrupole mass spectrometer , ion , detector , ion chromatography , selected reaction monitoring , tandem mass spectrometry , physics , organic chemistry , optics
Recently developed new techniques of ion formation from organic solids may become very useful in the application of mass spectrometers as detector units in liquid chromatography. Details of a liquid chromatograph mass spectrometer coupling device are presented. Some features of this device, combined with a quadrupole secondary ion mass spectrometer, are demonstrated experimentally by the analysis of aqueous solutions of leucine and cytosine. It is demonstrated that the sensitivity of the liquid chromatography secondary ion mass spectrometry combination covers the concentration range occurring in liquid chromatography.