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Mass spectral studies on steroidal compounds. VIII—a comparative study of 6‐ and 7‐oxalactones
Author(s) -
Ahmad M. S.,
Moinuddin G.,
Khan I. A.
Publication year - 1978
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210130704
Subject(s) - fragmentation (computing) , mass spectrum , cholestane , ion , chemistry , spectral line , mass spectrometry , analytical chemistry (journal) , computational chemistry , stereochemistry , chromatography , physics , organic chemistry , astronomy , computer science , operating system
The mass spectra of three steroidal ring B 7‐oxalactones and one 6‐oxalactone have been examined and comparison made with previously studied spectra of 6‐oxa isomers. Whereas the mass spectra of 6‐oxalactones are conspicuous by an intense peak at m / e 318, no such peak was found for 7‐oxalactones. On the contrary, the 7‐oxalactones showed characteristic [M CH 2 O] + ions. Thus, mass spectrometry offers an excellent means of differentiating between isomeric 6‐ and 7‐oxa ϵ‐lactones in the cholestane and β‐sitostane series. The fragmentation pathways suggested are supported by accurate mass measurement of some of the salient fragment ions.