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Mass spectrometry of 3‐substituted 4‐hydroxyisoquinolines and their derivatives
Author(s) -
Terent'ev P. B.,
Lomaki. P.,
Kost A. N.
Publication year - 1976
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210110308
Subject(s) - fragmentation (computing) , chemistry , ion , electron ionization , deuterium , mass spectrum , ether , mass spectrometry , aryl , high resolution , medicinal chemistry , stereochemistry , organic chemistry , alkyl , ionization , physics , chromatography , atomic physics , remote sensing , computer science , geology , operating system
Under electron impact, 3‐aryl‐4‐hydroxyisoquinolines form [M – H] + , [M – CO] + and [M – H – CO] + ions with a subsequent elimination of HCN or CH 3 CN. A cyclic structure for the [M – H] + ion is suggested. The primary act of fragmentation of the corresponding methyle ether derivatives is the loss of CH 3 ⋅, as well as H⋅; the further fragmentatio is similar to that described above. It has been established that the unusual [M – H] + , [M – OH] + and [M – CH 5 ⋅] + ions are formed when 8 fragments. Fragmentation schemes for all compounds are proposed based upon high resolution mass spectra and deuterated analogues.