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The mass spectra of potential antidiabetics: 4‐Arylhydrazono‐3‐methyl isoxazol‐5‐ones and pyrazol‐5‐ones
Author(s) -
Fenwick R. G.,
Garg H. G.
Publication year - 1973
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210070604
Subject(s) - moiety , fragmentation (computing) , mass spectrum , chemistry , medicinal chemistry , spectral line , stereochemistry , mass spectrometry , chromatography , physics , astronomy , computer science , operating system
The mass spectra of variously substituted 4‐arylhydrazono‐3‐methyl isoxazol‐5‐ones and pyrazol‐5‐ones have been examined, and the fragmentation pathways elucidated. The spectra of the former compounds differ from previously reported 4‐arylidene derivatives and this difference has been attributed to fragmentation involving the NHNmoiety. The investigation has shown up some interesting ‘ ortho effects’ as well as the facile loss of HNCNH from N‐amidino derivatives of the pyrazol‐5‐ones.