Premium
Mass spectra of macrolide antibiotics. The utility of the N‐oxide derivatives in enhancing fragmentation of the non‐sugar portion of basic antibiotics
Author(s) -
Mitscher L. A.,
Foltz R. L.,
Levenberg M. I.
Publication year - 1971
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210051013
Subject(s) - fragmentation (computing) , sugar , amino sugar , chemistry , antibiotics , mass spectrum , oxide , derivative (finance) , mass spectrometry , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , chromatography , biology , ecology , financial economics , economics
Fragmentation of macrolide antibiotics containing amino sugar moieties in the mass spectrometer provides limited structural information because amino sugar fragmentation dominates the spectrum. Formation of the N‐oxide derivative suppresses these processes and allows the non‐sugar portion to make a more substantial contribution to the spectrum. The N‐oxide may be formed in situ .