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Rearrangement and cyclization reactions in the mass spectra of a series of isatin carbonyl derivatives of medicinal interest: 2‐Oxo‐3‐indolinylidene anils (n‐arylketimines), 2‐oxo‐3‐indolinylidene phenylhydrazones, 2‐oxo‐3,3‐bis‐( o ‐diaminoaryl) indolyl deriv‐atives and their 2,3‐quinoxaline heterocyclic analogues
Author(s) -
Ballantine J. A.,
Fenwick R. G.,
Popp Frank D.
Publication year - 1971
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210050813
Subject(s) - isatin , mass spectrum , chemistry , fragmentation (computing) , cleavage (geology) , carbonyl group , medicinal chemistry , computational chemistry , stereochemistry , mass spectrometry , organic chemistry , chromatography , materials science , fracture (geology) , computer science , operating system , composite material
The mass spectra of several types of carbonyl derivatives of isatin have been examined and the fragmentation pathways have been studied. There are many differences from previously reported data on similar derivatives of less complex carbonyl compounds and several rearrangement processes have been shown to be involved in the cleavage reactions. Some interesting examples of ‘ ortho ‐effects’ have also come to light as a result of this investigation.