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A mass spectrometric study of 4‐hydroxy‐6‐methyl‐2‐pyridone and its derivatives
Author(s) -
Wulfson N. S.,
Zaikin V. G.,
Ziyavidinova Z. S.,
Burikov V. M.,
Mukerjee S. K.
Publication year - 1971
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210050613
Subject(s) - mass spectrum , chemistry , fragmentation (computing) , ion , medicinal chemistry , mass spectrometry , spectral line , 2 pyridone , stereochemistry , organic chemistry , chromatography , physics , astronomy , computer science , operating system
Abstract The mass spectra of 4‐hydroxy‐6‐methyl‐2‐pyridone, its N‐methyl and N‐phenyl derivatives, and also their 4‐O‐acetyl and 3‐C‐acyl derivatives have been studied. The proposed fragmentation pathways were supported by comparison of the mass spectra and in some cases by the spectra of deutero analogues. A strong N‐phenyl group effect has been found, which in the case of N‐phenyl‐4‐hydroxy‐ and N‐phenyl‐4‐acetoxy‐6‐methyl‐2‐pyridones promotes the formation of the stable [M—H]+ and [M—CH 3 CO]+ ions respectively. These ions are not characteristic of the N—H and N—Me analogues.