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The mass spectra of some s ‐triazolo[4,3‐a]pyrazines
Author(s) -
Potts K. T.,
Brugel E.
Publication year - 1971
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210050605
Subject(s) - chemistry , pyrazine , substituent , ring (chemistry) , mass spectrum , cyanamide , alkyl , polyatomic ion , triazole , medicinal chemistry , fragmentation (computing) , cyanide , ion , stereochemistry , organic chemistry , computer science , operating system
Abstract s ‐Triazolo[4,3‐a]pyrazine underwent decomposition by loss of nitrogen from its molecular ion whereas in the 3‐alkyl derivatives the corresponding alkyl cyanide was eliminated from the 5‐membered ring. The introduction of a carbonyl or thiocarbonyl group into the 3‐position resulted in predominant loss of the triazole ring in the fragmentation process; however, with a 3‐amino substituent, the first fragment eliminated from the molecular ion was cyanamide. Methyl substitution in the 6‐membered ring resulted in the formation of ring expanded ions. On phenyl substitution, however, an interesting 1,2‐phenyl migration was observed. The mass spectra of several analogous s ‐triazolo[1,5‐a]pyrazines are also described.