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The elucidation of the primary structure of the hypothalamic thyroid stimulating hormone releasing factor of ovine origin by means of mass spectrometry
Author(s) -
Desiderio Dominic M.,
Burgus Roger,
Dunn Thomas F.,
Vale Wylie,
Guillemin Roger,
Ward Darrell N.
Publication year - 1971
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210050212
Subject(s) - mass spectrometry , protein primary structure , chemistry , primary (astronomy) , endocrinology , medicine , hormone , biochemistry , chromatography , biology , peptide sequence , physics , astronomy , gene
This paper illustrates the role that mass spectrometry played in the first elucidation of the primary structure of a hypothalamic releasing factor. It has been demonstrated that ovine TRF has the structure 2‐pyrrolidone‐5‐carboxylyl‐histidyl‐proline amide.