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Mass spectrometry in cardenolide chemistry—II
Author(s) -
Blessington B.,
Nakagawa Y.,
Satoh D.
Publication year - 1970
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210040124
Subject(s) - cardenolide , chemistry , acetylation , mass spectrometry , mass spectrum , computational chemistry , organic chemistry , chromatography , biochemistry , glycoside , gene
Six partial acetates of gitoxin have been used to establish the value of mass spectrometry, when used in conjunction with deuteroacetylation, in cardenolide structural studies. This technique permits the unambiguous location of acetyl groups upon any of the digitoxose residues, and in some cases confirms acetylation of C 16 of the steroid ring. The method is suitable for metabolic studies. The spectra discussed show that neither acetyl exchange nor acetyl migration reactions had taken place during the deuteroacetylation step.