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Mass‐spectrometric studies on alkylated 6‐thiopurines
Author(s) -
Deutsch Joseph,
Neiman Zohar,
Bergmann Felix
Publication year - 1970
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210030909
Subject(s) - alkyl , chemistry , alkylation , fragmentation (computing) , ring (chemistry) , mass spectrum , ion , medicinal chemistry , hypoxanthine , stereochemistry , organic chemistry , biology , ecology , enzyme , catalysis
6‐Thiopurine and its N ‐ or C ‐alkyl derivatives all form an [M – 1]‐ion upon fragmentation. In the 7‐alkyl derivatives, this ion represents the major component of the spectrum. This is ascribed to formation of a five‐membered thiazoline‐like ring. Similar ring formation stabilises the [M – 1]‐ion in the 7‐methyl derivatives of hypoxanthine, adenine and 6‐selenopurine.