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The mass spectra of griseofulvin analogues. Characteristic fragmentation processes in the mass spectra of spiro‐cyclohexenones and spiro‐cyclohexanones containing the griseofulvin skeleton
Author(s) -
Ballantine J. A.,
Fenwick R. G.
Publication year - 1969
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210021112
Subject(s) - griseofulvin , mass spectrum , degree of unsaturation , chemistry , fragmentation (computing) , ring (chemistry) , cyclohexane , spectral line , stereochemistry , double bond , crystallography , mass spectrometry , organic chemistry , physics , biology , medicine , pathology , chromatography , astronomy , ecology
The mass spectra of a number of griseofulvin analogues have been examined and the fragmentations, which are characteristic of the basic skeleton of the molecule, have been determined. In all of the different structural types examined, the ring cleavages which predominate are found tol occur by fission of one or more of the bonds attached to the spiro carbon atom. The degree of unsaturation in the spiro‐cyclohexane ring system is found to controll the type of fragmentation which occurs and the type of ring system which is present can therefore be identified by its mass spectrum.