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Pharmacologically interesting compounds—I: High resolution mass spectra of phenothiazines
Author(s) -
Gilbert J. N. T.,
Millard B. J.
Publication year - 1969
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210020103
Subject(s) - phenothiazine , substituent , chemistry , ring (chemistry) , side chain , mass spectrum , ion , high resolution , fragmentation (computing) , stereochemistry , crystallography , organic chemistry , medicine , remote sensing , computer science , pharmacology , operating system , geology , polymer
The mass spectra of twenty‐six commercially available medicinal phenothiazines have been determined at high resolution. In each compound, the side chain attached to the 10‐position of the phenothiazine ring contains nitrogen and fission of the CC bond α to this nitrogen gives in most cases the base peak. Some of the compounds are also substituted at the 2‐position and this substituent generally remains intact, though some substituents such as acetyl, propionyl, methoxyl and methylthio can undergo fragmentation. Fragmentations fall into three groups; those which give ions representing a part of the side chain; those which give ions representing the intact phenothiazine ring with part of the side chain attached; those which give ions representing a partially fragmented ring system.