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The mass spectra of some C‐19 modified cholesteryl derivatives
Author(s) -
KirkienKonasiewicz Alijca M.,
Moriarty Robert M.,
Loudon Alexander G.,
Cardnell Peter M.
Publication year - 1968
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210010411
Subject(s) - fragmentation (computing) , chemistry , mass spectrum , ion , electron ionization , metastability , hydrogen , acetic acid , pyrolysis , molecule , polyatomic ion , spectral line , analytical chemistry (journal) , medicinal chemistry , organic chemistry , physics , computer science , ionization , operating system , astronomy
The mass spectra of twenty one C‐19 modified cholesteryl derivatives have been determined and compared with results for related systems. In the case when the hydrogen(s) of the C‐19 group have been replaced by other groups the metastable evidence shows that in those molecules with a C‐3 hydroxyl group the loss of water followed by the loss of the C‐19 group gives rise to an intense ion at m / e 353, whereas the loss of the C‐19 group with hydrogen transfer to the ion, followed by the loss of water gives rise to the large ion at m / e 354. In contrast in the case of the C‐3 acetates the main fragmentation is the loss of acetic acid followed by the loss of the C‐19 group to give the ion at m / e 353. This is rationalised on the basis of results observed in other systems. In the case of the C‐3 tosylates evidence for pyrolysis before electron impact fragmentation is presented. The subsequent fragmentation of the large ions at m / e 354, 353 and other m / e values in the high mass region is shown to be in line with earlier work.