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Amino‐acid sequence study in peptides by mass spectometry—III Investigation of ethyoxycarbonyl‐peptide methyl esters
Author(s) -
Kamerling J. P.,
Heerma W.,
Vliegenthart J. F. G.
Publication year - 1968
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210010305
Subject(s) - peptide , chemistry , fragmentation (computing) , glutathione , mass spectrometry , amino acid , stereochemistry , peptide sequence , chromatography , biochemistry , biology , ecology , enzyme , gene
The utility of ethoxycarbonyl‐peptide methyl esters for mass spectrometric analysis is described. The ethoxycarbonyl group has important advantages over other protecting groups which are in use. The derivatives have high intensity; this greatly facilitates the interpretation of the fragmentation pattern. The spentra of the methyl esters of the ethoxycarbonyl derivatives of pro‐val, trp‐gly, gly‐ser, (cys) 2 , glutation (GSH), glu‐his‐phe, val‐tyr‐pro and val‐lys‐val‐tyr‐pro are given.