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‘Mass spectrometry of vitamin B 6 : Different forms of the vitamin, its metabolites, antimetabolites, and analogs’
Author(s) -
Dejongh D. C.,
Perricone S. C.,
Gay M. L.,
Korytnyk W.
Publication year - 1968
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210010114
Subject(s) - pyridoxamine , chemistry , pyridoxal , lactone , vitamin , pyridoxine , mass spectrum , pyridoxine hydrochloride , mass spectrometry , vitamin b6 , stereochemistry , organic chemistry , biochemistry , chromatography , enzyme
The mass spectra of the different forms of vitamin B 6 , some metabolites and antimetabolites, and some analogs are reported. The free bases are suitable for study, but the 5‐phosphates are not sufficiently volatile. The hydrochloride salts dissociate thermally in the inlet system into the free base and HCl and give the spectrum of the free base with the spectrum of HCL superimposed on it. The compounds studied are: pyridoxol, pyridoxamine and pyridoxal, which are different forms of vitamin B 6 ; 4‐pyridoxic acid and its lactone, 5‐pyridoxic acid lactone, isopyridoxal, 5‐formyl‐3‐hydroxy‐2‐methylpyridine‐4‐carboxylic acid, and 3‐hydroxy‐2‐methylpyridine‐4,5‐dicarboxylic acid, which are vitamin B 6 metabolites; α 4 ‐and α 5 ‐deoxypyridoxol, 3‐deoxypyridoxol, and 4‐ and 5‐ norpyridoxol, which are antimetabolites and analogs of vitamin B 6 .