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Nitrogen‐15 NMR studies of 1,4‐benzodiazepines: 2 —The triazolobenzodiazepines
Author(s) -
Scahill Terrence A.,
Smith Stanford L.
Publication year - 1983
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/omr.1270211104
Subject(s) - substituent , chemical shift , chemistry , protonation , reagent , nitrogen , alprazolam , medicinal chemistry , organic chemistry , ion , psychology , anxiety , psychiatry
Nitrogen‐15 NMR data for a series of 21 triazolobenzodiazepines are presented, including 15 N chemical shifts and substituent effects. The line assignments made by correlation to other model compounds were confirmed by a shift reagent and protonation study. A Yb(dpm) 3 study on alprazolam showed that the molar shifts of the four nitrogens ranged from 35 to 150 ppm.