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Hydroxy group substituent effects on 1 H NMR chemical shifts in the structural elucidation of spirostanes
Author(s) -
Jaffer Jaffer A.,
Crabb Trevor A.,
Turner Christopher H.,
Blunden Gerald
Publication year - 1983
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/omr.1270210913
Subject(s) - substituent , chemical shift , methylene , chemistry , proton , nuclear magnetic resonance spectroscopy , decoupling (probability) , proton nmr , group (periodic table) , spectroscopy , stereochemistry , computational chemistry , crystallography , medicinal chemistry , organic chemistry , physics , quantum mechanics , control engineering , engineering
1 H NMR chemical shifts in spirostanes have been determined by spin‐decoupling difference spectroscopy. Substituent effects of 7β‐OH on 15‐methylene proton shifts, 1β‐OH on 11α‐ and 2α‐proton shifts and 6α‐OH on 4α‐proton shifts have been determined and used in the structural assignment of spirostanes.