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1 H and 13 C NMR spectra of 1‐palmitoyl‐2‐oleyl‐ sn ‐glycero‐3‐phosphorylcholine in CDCl 3 solution and in sonicated dispersions in 2 H 2 O
Author(s) -
Santaren Juan F.,
Rico M.,
Ribera A.
Publication year - 1983
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/omr.1270210403
Subject(s) - lecithin , chemistry , phospholipid , molecule , relaxation (psychology) , phosphorylcholine , crystallography , alkyl , organic chemistry , chromatography , membrane , biochemistry , psychology , social psychology
A mixed‐acid monounsaturated lecithin, 1‐palmitoyl‐2‐oleyl‐ sn ‐glycero‐3‐phosphorylcholine (POL), has been synthesized by phospholipase A 2 digestion of 1,2 dipalmitoyl‐ sn ‐glycero‐3‐phosphorylcholine followed by reacylation of the lysolecithin with oleic anhydride. 1 H (90 MHz) and 13 C (25.2 MHz) NMR spectra of POL in CDCl 3 solution and in sonicated dispersions in 2 H 2 O have been obtained, and spin‐lattice relaxation times measured. The relaxation times were characteristic of the type of structure formed and reflect molecular motion within the lecithin molecule in each structure. In both systems the spin‐lattice relaxation times increase along the alkyl chains towards the terminal methyl group, showing a corresponding increase in the chain molecular motion, although there are significant differences in the gradation of the changes.