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Optimal efficacy of ribavirin in the treatment of hepatitis C
Author(s) -
Chakrabarty Siddhartha P.
Publication year - 2009
Publication title -
optimal control applications and methods
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.458
H-Index - 44
eISSN - 1099-1514
pISSN - 0143-2087
DOI - 10.1002/oca.894
Subject(s) - ribavirin , optimal control , medicine , hepatitis c , interferon , clinical efficacy , chronic hepatitis , virology , mathematical optimization , computer science , mathematics , virus
A mathematical model to represent hepatitis C is presented. An objective functional keeping biomedical goals in mind is formulated. The optimal control problem is solved numerically to obtain an optimal efficacy of ribavirin in a combination treatment of ribavirin with interferon, where the efficacy of the latter has a clinically validated functional form. Copyright © 2009 John Wiley & Sons, Ltd.