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Nucleus accumbens microstructure mediates the relationship between obesity and eating behavior in adults
Author(s) -
Samara Amjad,
Li Zhaolong,
Rutlin Jerrel,
Raji Cyrus A.,
Sun Peng,
Song ShengKwei,
Hershey Tamara,
Eisenstein Sarah A.
Publication year - 2021
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.23201
Subject(s) - nucleus accumbens , putamen , basal ganglia , caudate nucleus , reward system , obesity , medicine , psychology , basal (medicine) , endocrinology , brain stimulation reward , neuroscience , dopamine , central nervous system , insulin
Abstract Objective Basal ganglia regions are part of the brain’s reward‐processing networks and are implicated in the neurobiology of obesity and eating disorders. This study examines basal ganglia microstructural properties in adults with and without obesity. Methods Diffusion basis spectrum imaging (DBSI) images were analyzed to obtain putative imaging markers of neuroinflammation. Relationships between basal ganglia DBSI metrics and reward sensitivity and eating behaviors were also explored. Results A total of 46 participants (25 people with obesity; aged 20‐40 years; 37 women) were included. Relative to the people in the normal‐weight group, people with obesity had smaller caudate and larger nucleus accumbens (NAcc) volumes ( p < 0.05) and lower DBSI fiber fraction (reflecting apparent axonal/dendrite density) in NAcc and putamen, higher DBSI nonrestricted fraction (reflecting tissue edema) in NAcc and caudate, and higher DBSI restricted fraction (reflecting tissue cellularity) in putamen ( p ≤ 0.01, all). Increased emotional and reward eating behaviors were related to lower NAcc axonal/dendrite density and greater tissue edema ( p ≤ 0.002). The relationships between emotional eating and adiposity measures were mediated by NAcc microstructure. Conclusions These findings provide evidence that microstructural alterations in basal ganglia relate to obesity and insights linking NAcc microstructure and eating behavior in adults.