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Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and β‐Cell Function
Author(s) -
Xiang Anny H.,
Martinez Mayra P.,
Trigo Enrique,
Utzschneider Kristina M.,
CreeGreen Melanie,
Arslanian Silva A.,
Ehrmann David A.,
Caprio Sonia,
Mohamed Passant H. I. H.,
Hwang Darryl H.,
Katkhouda Namir,
Nayak Krishna S.,
Buchanan Thomas A.
Publication year - 2021
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.23174
Subject(s) - medicine , prediabetes , glycemic , type 2 diabetes , endocrinology , insulin , insulin resistance , diabetes mellitus , obesity , weight loss , arginine , biology , biochemistry , amino acid
Objective The aim of this study was to examine the relationship between changes in liver fat and changes in insulin sensitivity and β‐cell function 2 years after gastric banding surgery. Methods Data included 23 adults with the surgery who had prediabetes or type 2 diabetes for less than 1 year and BMI 30 to 40 kg/m 2 at baseline. Body adiposity measures including liver fat content (LFC), insulin sensitivity (M/I), and β‐cell responses (acute, steady‐state, and arginine‐stimulated maximum C‐peptide) were assessed at baseline and 2 years after surgery. Regression models were used to assess associations adjusted for age and sex. Results Two years after surgery, all measures of body adiposity, LFC, fasting and 2‐hour glucose, and hemoglobin A1c significantly decreased; M/I significantly increased; and β‐cell responses adjusted for M/I did not change significantly. Among adiposity measures, reduction in LFC had the strongest association with M/I increase ( r = −0.61, P = 0.003). Among β‐cell measures, change in LFC was associated with change in acute C‐peptide response to arginine at maximal glycemic potentiation adjusted for M/I ( r = 0.66, P = 0.007). Significant reductions in glycemic measures and increase in M/I were observed in individuals with LFC loss >2.5%. Conclusions Reduction in LFC after gastric banding surgery appears to be an important factor associated with long‐term improvements in insulin sensitivity and glycemic profiles in adults with obesity and prediabetes or early type 2 diabetes.