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Multiomic Predictors of Short‐Term Weight Loss and Clinical Outcomes During a Behavioral‐Based Weight Loss Intervention
Author(s) -
Siebert Janet C.,
Stanislawski Maggie A.,
Zaman Adnin,
Ostendorf Danielle M.,
Konigsberg Iain R.,
Jambal Purevsuren,
Ir Diana,
Bing Kristen,
Wayland Liza,
Scorsone Jared J.,
Lozupone Catherine A.,
Görg Carsten,
Frank Daniel N.,
Bessesen Daniel,
MacLean Paul S.,
Melanson Edward L.,
Catenacci Victoria A.,
Borengasser Sarah J.
Publication year - 2021
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.23127
Subject(s) - weight loss , medicine , overweight , waist , obesity , body mass index
Objective Identifying predictors of weight loss and clinical outcomes may increase understanding of individual variability in weight loss response. We hypothesized that baseline multiomic features, including DNA methylation (DNAme), metabolomics, and gut microbiome, would be predictive of short‐term changes in body weight and other clinical outcomes within a comprehensive weight loss intervention. Methods Healthy adults with overweight or obesity ( n = 62, age 18‐55 years, BMI 27‐45 kg/m 2 , 75.8% female) participated in a 1‐year behavioral weight loss intervention. To identify baseline omic predictors of changes in clinical outcomes at 3 and 6 months, whole‐blood DNAme, plasma metabolites, and gut microbial genera were analyzed. Results A network of multiomic relationships informed predictive models for 10 clinical outcomes (body weight, waist circumference, fat mass, hemoglobin A 1c , homeostatic model assessment of insulin resistance, total cholesterol, triglycerides, C‐reactive protein, leptin, and ghrelin) that changed significantly ( P < 0.05). For eight of these, adjusted R 2 ranged from 0.34 to 0.78. Our models identified specific DNAme sites, gut microbes, and metabolites that were predictive of variability in weight loss, waist circumference, and circulating triglycerides and that are biologically relevant to obesity and metabolic pathways. Conclusions These data support the feasibility of using baseline multiomic features to provide insight for precision nutrition–based weight loss interventions.