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Antidepressant Medications and Weight Change: A Narrative Review
Author(s) -
Gill Hartej,
Gill Barjot,
ElHalabi Sabine,
ChenLi David,
Lipsitz Orly,
Rosenblat Joshua Daniel,
Van Rheenen Tamsyn E.,
Rodrigues Nelson B.,
Mansur Rodrigo B.,
Majeed Amna,
Lui Leanna M. W.,
Nasri Flora,
Lee Yena,
Mcintyre Roger S.
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22969
Subject(s) - mirtazapine , weight gain , antidepressant , medicine , adverse effect , weight loss , bupropion , weight change , appetite , escitalopram , psychiatry , body weight , obesity , anxiety , smoking cessation , pathology
Antidepressant medications are the first‐line treatment option for moderate to severe major depressive disorder. However, most antidepressants have numerous documented adverse events, including cardiometabolic effects and weight gain, which are major public health concerns. Antidepressant agents provide varying risk of associated weight gain, including significant within‐class differences. Some agents, such as mirtazapine, show significant levels of weight gain, while others, such as bupropion, demonstrate weight‐loss effects. Current findings suggest the role of histamine and serotonin off‐target appetite‐promoting pathways in adverse weight‐gain effects. Therefore, controlling for undesired weight effects is an important consideration for the selection of antidepressants.