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Associations of Gestational Weight Gain Rate During Different Trimesters with Early‐Childhood Body Mass Index and Risk of Obesity
Author(s) -
Xiong Xin,
Xia Wei,
Li Yuanyuan,
Xu Shunqing,
Zhang Yaqi
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22963
Subject(s) - overweight , medicine , body mass index , obesity , obstetrics , odds ratio , weight gain , offspring , pregnancy , gestational diabetes , birth weight , gestational age , gestation , body weight , biology , genetics
Objective This study aimed to estimate the associations of gestational weight gain rate (GWGR) during different trimesters with offspring growth and overweight/obesity risk. Methods The study included 4,807 mother‐infant pairs enrolled in Wuhan, China. GWGR in each trimester was used as a continuous and a categorical variable to estimate the associations with offspring BMI z score (ZBMI) and overweight/obesity risk between 0 and 2 years. Results Greater GWGR (per 0.2 kg/wk) in the first, second, and third trimester was positively associated with offspring ZBMI across birth to 2 years old (β 0.06 [95% CI: 0.04‐0.09], β 0.13 [95% CI: 0.09‐0.16], and β 0.04 [95% CI: 0.02‐0.07], respectively). Excessive GWGR in the first trimester (≥ 0.30 kg/wk) was associated with an odds ratio (OR) of 1.58 (95% CI: 1.18‐2.13) and 1.37 (95% CI: 1.11‐1.71) for macrosomia and 2‐year overweight/obesity, respectively. Excessive GWGR in the second trimester was associated with an OR of 2.09 (95% CI: 1.42‐3.08), 1.21 (95% CI: 1.02‐1.43), and 1.48 (95% CI: 1.15‐1.90) for macrosomia, 1‐year, and 2‐year overweight/obesity, respectively. Excessive GWGR in the third trimester was associated with an OR of 1.91 (95% CI: 1.27‐2.86) and 1.32 (95% CI: 1.02‐1.72) for macrosomia and 2‐year overweight/obesity, respectively. Conclusions Excessive GWGR in each trimester was positively associated with offspring ZBMI and early‐childhood overweight/obesity risk.