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Opposite Association of Adropin Concentrations with Obesity in Prepubertal Children Compared with Adolescents
Author(s) -
Herrero Leticia,
Dios Olaya,
GavelaPérez Teresa,
Riestra Pía,
Jois Asha,
SorianoGuillén Leandro,
Garcés Carmen
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22886
Subject(s) - medicine , endocrinology , obesity , leptin , childhood obesity , hormone , overweight
Objective The aim of this study was to evaluate the association between obesity and plasma adropin levels in two cohorts of children at two different ages. Methods Adropin concentrations were measured in 71 prepubertal and 41 pubertal children with obesity and their age‐ and sex‐matched normal weight counterparts (69 prepubertal and 42 pubertal children). Information was available in these children on insulin levels, lipid profile, and leptin levels. Adropin levels were measured by using a commercial enzyme‐linked immunosorbent assay kit. Results Plasma adropin levels were significantly higher ( P < 0.001) in prepubertal than pubertal children. Adropin concentrations were significantly higher ( P < 0.001) in prepubertal girls than in prepubertal boys but significantly lower ( P < 0.001) in pubertal girls than in pubertal boys. Prepubertal boys and girls with obesity had significantly higher adropin levels ( P < 0.001) than their normal weight counterparts. In contrast, no differences in adropin levels were observed in pubertal children when comparing children with obesity and normal weight boys and girls. Conclusions An important decrease in adropin levels in pubertal children compared with prepubertal children was shown as well as a differing association of adropin with obesity depending on age. These findings suggest a possible relationship between adropin levels and centrally regulated sex hormones involved in pubertal development.