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Human Milk Oligosaccharides and Hispanic Infant Weight Gain in the First 6 Months
Author(s) -
Berger Paige K.,
Plows Jasmine F.,
Jones Roshonda B.,
Alderete Tanya L.,
Yonemitsu Chloe,
Ryoo Ji Hoon,
Bode Lars,
Goran Michael I.
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22884
Subject(s) - weight gain , medicine , infant formula , obesity , birth weight , body weight , physiology , pediatrics , pregnancy , biology , genetics
Objective The aim of this study was to determine whether human milk oligosaccharides (HMOs) at 1 month predicted infant weight gain at 6 months and whether associations varied by HMO secretor status. Methods Participants were 157 Hispanic mother‐infant pairs. Human milk samples were collected at 1 month. Nineteen individual HMOs were analyzed using high‐performance liquid chromatography, and secretor status was determined by the presence of 2′‐fucosyllactose or lacto‐ N ‐fucopentaose (LNFP) I. Infant weight was measured at 1 and 6 months. Path analysis was used to test effects of HMO composition on infant weight gain, adjusting for maternal age, prepregnancy BMI, and infant age, sex, and birth weight. Results In the total sample, higher LNFPII predicted lower infant weight gain ( g 1 = −4.1, P = 0.004); this was observed in both nonsecretor ( g 1 = −3.0, P = 0.006) and secretor groups ( g 1 = −4.7, P = 0.014). In the nonsecretor group, higher lacto‐ N ‐neotetraose ( g 1 = 7.6, P = 0.011) and disialyllacto‐ N ‐tetraose ( g 1 = 14.3, P = 0.002) predicted higher infant weight gain. There were no other associations in the secretor group. Conclusions Our data suggest that higher LNFPII in human milk may decrease obesity risk across all infants, whereas higher lacto‐N‐neotetraose and disialyllacto‐N‐tetraose may increase obesity risk in infants of nonsecretors only.