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Changes in Cardiometabolic Risk Factors Before and After Gestational Diabetes: A Prospective Life‐Course Analysis in CARDIA Women
Author(s) -
Catov Janet M.,
Sun Baiyang,
Bertolet Marnie,
Snyder Gabrielle G.,
Lewis Cora E.,
Allen Norrina B.,
Shikany James M.,
Ingram Katherine H.,
Appiah Duke,
Gunderson Erica P.
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22848
Subject(s) - gestational diabetes , medicine , obstetrics , waist , diabetes mellitus , pregnancy , prospective cohort study , weight gain , birth weight , parity (physics) , obesity , gestation , endocrinology , body weight , genetics , biology , physics , particle physics
Objective This study hypothesized that both preconception and postchildbearing patterns of cardiometabolic risk factors may be different for women with gestational diabetes mellitus (GDM) compared with women without GDM. Methods Among 1,302 (51% black) women in the Coronary Artery Risk Development in Young Adults (CARDIA) study with births and followed for 30 years, this study evaluated changes in cardiometabolic factors (BMI, waist circumference [WC], lipids, blood pressure) during prechildbearing (prior to the first postbaseline birth) and postchildbearing periods (after the last birth) by GDM status using piecewise linear mixed models adjusted for sociodemographics, parity, and time‐varying covariates. Results Compared with women who did not develop GDM, weight and WC increases in women who developed GDM ( n = 152, 12%) were faster (BMI difference: +0.12 kg/m 2 /y, P = 0.04; WC difference: +0.28 cm/y, P = 0.04) during the prechildbearing period, accounting for covariates. This translated to an average of 1.3 kg of excess weight gain across 4 years among women with subsequent GDM versus non‐GDM births. In contrast, slopes after childbearing did not differ by GDM status, nor were there other cardiometabolic differences. Conclusions Women with GDM exhibited an increasing prepregnancy pattern of weight gain and central adiposity. Absolute postchildbearing weight was also higher in GDM‐affected women, but the slope of gain after GDM was not.