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Abnormal Regional Neural Activity and Reorganized Neural Network in Obesity: Evidence from Resting‐State fMRI
Author(s) -
Zhang Peng,
Wu Guowei,
Yu Fengxia,
Liu Yang,
Li Mengyi,
Wang Zheng,
Ding Heyu,
Li Xiaoshuai,
Wang Hao,
Jin Mei,
Zhang Zhengyu,
Zhao Pengfei,
Li Jing,
Yang Zhenghan,
Lv Han,
Zhang Zhongtao,
Wang Zhenchang
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22839
Subject(s) - parahippocampal gyrus , fusiform gyrus , limbic lobe , functional magnetic resonance imaging , neuroscience , resting state fmri , hippocampus , amygdala , psychology , lingual gyrus , superior temporal gyrus , neuropsychology , gyrus , neural correlates of consciousness , dentate gyrus , fusiform face area , medicine , audiology , temporal lobe , cognition , face perception , perception , epilepsy
Objective This study aimed to investigate regional neural activity and regulation of patterns in the reorganized neural network of obesity and explore the correlation between brain activities and eating behavior. Methods A total of 23 individuals with obesity and 23 controls with normal weight were enrolled. Functional magnetic resonance imaging (fMRI) data were acquired using 3.0‐T MRI. Amplitude of low‐frequency fluctuation and functional connectivity (FC) analyses were conducted using Data Processing Assistant for resting‐state fMRI and Resting‐State fMRI Data Analysis Toolkit (REST). Results The group with obesity showed increased amplitude of low‐frequency values in left fusiform gyrus/amygdala, inferior temporal gyrus (ITG), hippocampus/parahippocampal gyrus, and bilateral caudate but decreased values in right superior temporal gyrus. The group with obesity showed increased FC between left caudate and right superior temporal gyrus, left fusiform gyrus/amygdala and left ITG, right caudate and left fusiform gyrus/amygdala, and right caudate and left hippocampus/parahippocampal gyrus. Dutch Eating Behavior Questionnaire‐Emotional scores were positively correlated with FC between left hippocampus/parahippocampal gyrus and right caudate but negatively correlated with FC between left fusiform gyrus/amygdala and left ITG. Conclusions The study indicated the reorganized neural network presented as a bilateral cross‐regulation pattern across hemispheres between reward and various appetite‐related functional processing, thus affecting emotional and external eating behavior. These results could provide further evidence for neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential in obesity.