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Baseline Metabolic Variables Do Not Predict Weight Regain in Premenopausal Women
Author(s) -
Martins Catia,
Gower Barbara A.,
Hunter Gary R.
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22780
Subject(s) - weight loss , respiratory quotient , medicine , overweight , obesity , basal metabolic rate , endocrinology , weight gain , body weight
Objective The aim of this study was to investigate whether baseline (pre–weight loss) metabolic variables can predict weight regain. Methods About 117 women with overweight completed a weight loss program to achieve BMI < 25 kg/m 2 and were followed for 2 years. Resting metabolic rate, respiratory quotient, insulin sensitivity, and serum leptin concentration were measured pre–weight loss, while on energy balance, and as predictors of weight regain at 1 and 2 years. Rate and amount of weight loss also were examined as predictors, as these outcomes may reflect metabolic phenotype. Results Average weight loss was 12 (SD 2.5) kg, and regain was 48% (SD 35%) and 80% (SD 52%) at 1 and 2 years, respectively. In regression modeling, metabolic variables (both pre–weight loss and changes with weight loss) did not predict weight regain. However, initial weight loss and time to achieve BMI < 25 were significant predictors of weight regain at 1 and 2 years, even after adjusting for confounders. Conclusions Baseline (pre–weight loss) resting metabolic rate, respiratory quotient, insulin sensitivity, and leptin did not predict weight regain. However, a larger and faster weight loss was associated with a lower weight regain. Understanding the mechanisms behind interindividual variation in magnitude and rate of weight loss is needed to ensure better weight loss maintenance.