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Maternal Glucose Concentrations in Early Pregnancy and Cardiometabolic Risk Factors in Childhood
Author(s) -
Wahab Rama J.,
Voerman Ellis,
Jansen Pauline W.,
Oei Edwin H.G.,
Steegers Eric A.P.,
Jaddoe Vincent W.V.,
Gaillard Romy
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22771
Subject(s) - medicine , pregnancy , insulin , offspring , overweight , endocrinology , gestational diabetes , population , prospective cohort study , insulin resistance , obstetrics , gestation , body mass index , biology , environmental health , genetics
Objective This study aimed to examine the associations of maternal early‐pregnancy glucose and insulin concentrations with offspring cardiometabolic risk factors and fat distribution. Methods In a population‐based prospective cohort study among 3,737 mothers and their children, random maternal glucose and insulin concentrations were measured at a median gestational age of 13.2 (95% range 10.5‐17.1) weeks. Childhood fat, blood pressure, and blood concentrations of lipids, glucose, and insulin at the age of 10 years were measured. Results Higher maternal early‐pregnancy glucose and insulin concentrations were associated with a higher risk of childhood overweight, and higher maternal early‐pregnancy insulin concentrations were associated with an increased childhood risk of clustering of cardiometabolic risk factors (all P < 0.05). These associations were explained by maternal prepregnancy BMI. Independent of maternal prepregnancy BMI, one SD score (SDS) higher maternal early‐pregnancy glucose and insulin concentrations were associated with higher childhood glucose (0.08 SDS, 95% CI: 0.04‐0.11) and insulin concentrations (0.07 SDS, 95% CI: 0.03‐0.10), but not with childhood blood pressure, lipids, and fat measures. Conclusions These results suggest that maternal early‐pregnancy random glucose and insulin concentrations are associated with childhood glucose and insulin concentrations but not with other childhood cardiometabolic risk factors.