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Altered Interactions Among Resting‐State Networks in Individuals with Obesity
Author(s) -
Ding Yueyan,
Ji Gang,
Li Guanya,
Zhang Wenchao,
Hu Yang,
Liu Lei,
Wang Yuanyuan,
Hu Chunxin,
Deneen Karen M.,
Han Yu,
Cui Guangbin,
Wang Huaning,
Wiers Corinde E.,
Manza Peter,
Tomasi Dardo,
Volkow Nora D.,
Nie Yongzhan,
Wang GeneJack,
Zhang Yi
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22731
Subject(s) - default mode network , overeating , precuneus , functional magnetic resonance imaging , anterior cingulate cortex , prefrontal cortex , resting state fmri , ventromedial prefrontal cortex , posterior cingulate , neuroscience , dorsolateral prefrontal cortex , psychology , craving , medicine , audiology , addiction , cognition , obesity
Objective The aim of this study was to investigate alterations in functional connectivity (FC) within and interactions between resting‐state networks involved in salience, executive control, and interoception in participants with obesity (OB). Methods Using resting‐state functional magnetic resonance imaging with independent component analysis and FC, alterations within and interactions between resting‐state networks in 35 OB and 35 normal‐weight controls (NW) were investigated. Results Compared with NW, OB showed reduced FC strength in the ventromedial prefrontal cortex and posterior cingulate cortex/precuneus within the default‐mode network, dorsal anterior cingulate cortex within the salience network (SN), bilateral dorsolateral prefrontal cortex‐angular gyrus within the frontoparietal network (FPN), and increased FC strength in the insula (INS) ( P familywise error < 0.0125). The dorsal anterior cingulate cortex FC strength was negatively correlated with craving for food cues, left dorsolateral prefrontal cortex FC strength was negatively correlated with Yale Food Addiction Scale scores, and right INS FC strength was positively correlated with craving for high‐calorie food cues. Compared with NW, OB also showed increased FC between the SN and FPN driven by altered FC of bilateral INS and anterior cingulate cortex‐angular gyrus. Conclusions Alterations in FC within and interactions between the SN, default‐mode network, and FPN might contribute to the high incentive value of food (craving), lack of control of overeating (compulsive overeating), and increased awareness of hunger (impaired interoception) in OB.