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Alterations of Serum Ser312‐Phosphorylated Fetuin‐A from Exercise‐Induced Moderate Body Weight Loss in Individuals with Obesity
Author(s) -
Ren Guang,
Bowers Robert L.,
Kim Teayoun,
ArayaRamirez Felipe,
Mahurin A. Jack,
Dean David M.,
Grandjean Peter W.,
Mathews Suresh T.
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22730
Subject(s) - weight loss , insulin resistance , medicine , endocrinology , insulin , obesity , adipose tissue , body mass index
Objective Phosphorylated fetuin‐A (pFet‐A) inhibits insulin action and has been shown to be associated with obesity and insulin resistance. The objective of this cohort study was to assess the effect of incremental body weight loss on alterations in serum pFet‐A and indexes of insulin sensitivity. Methods A total of 16 men with obesity attained a targeted weight loss of 8% to 10% of their initial body weight by achieving an energy expenditure/deficit of 2,000 to 2,500 kcal/wk. Anthropometric assessments and blood samples were obtained every 4 weeks. Weight loss was calculated and partitioned as 2% to 4%, 4% to 6%, 6% to 8%, and 8% to 10% compared with initial body weight. Results Targeted body weight loss of 8% to 10% decreased serum pFet‐A, pFet‐A:Fet‐A ratio, fasting insulin, log(homeostasis model assessment of insulin resistance), quantitative insulin sensitivity check index, adipose insulin resistance, and insulin resistance index significantly. Percent changes in serum pFet‐A were associated with percent changes in indexes of insulin sensitivity. Unlike insulin sensitivity indexes, which were altered starting with 6% to 8% weight loss, serum pFet‐A levels were significantly decreased by 19.6% starting with 2% to 4% weight loss and decreased by 25.6%, 36.8%, and 42.3% with 4% to 6%, 6% to 8%, and 8% to 10% weight loss, respectively. Conclusions This study reports for the first time that the insulin‐sensitizing effects of moderate weight loss are associated with a reduction in serum pFet‐A levels.