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Effect of Weight Change Following Intentional Weight Loss on Bone Health in Older Adults with Obesity
Author(s) -
Kammire Daniel E.,
Walkup Michael P.,
Ambrosius Walter T.,
Lenchik Leon,
Shapses Sue A.,
Nicklas Barbara J.,
Houston Denise K.,
Marsh Anthony P.,
Rejeski W. Jack,
Beavers Kristen M.
Publication year - 2019
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22604
Subject(s) - medicine , weight loss , bone mineral , obesity , weight change , trabecular bone score , femoral neck , bone density , body mass index , osteoporosis , physical therapy , quantitative computed tomography
Objective This study aimed to examine change in bone mineral density (BMD) and trabecular bone score among older adult weight regainers (WR) and weight maintainers (WM). Methods Observational data come from 77 older adults (mean age: 67 [SD 5] years; 69% women; 70% white) with obesity (mean BMI: 33.6 [SD 3.7] kg/m 2 ) who lost weight during an 18‐month weight loss intervention. Total body mass and body composition, along with regional (total hip, femoral neck, lumbar spine) BMD and trabecular bone score, were measured at baseline, 18 months, and 30 months. WR ( n = 36) and WM ( n = 41) categories were defined as a ≥ 5% or < 5% weight gain from 18 to 30 months, respectively. Results Among skeletal indices, only total hip BMD was significantly reduced during the 18‐month intervention period in both WRs (−3.9%; 95% CI: −5.8% to −2.0%) and WMs (−2.4%; 95% CI: −4.3% to −0.5%; P = 0.07). After adjustment for relevant baseline covariates and weight change from 0 to 18 months, 30‐month change in total hip BMD was −2.6% (95% CI: −4.3% to −0.9%) and −3.9% (95% CI: −5.7% to −2.1%) among WRs and WMs, respectively ( P = 0.07). Conclusions Loss of hip BMD persists in the year after a weight loss intervention among older adults with obesity, regardless of weight regain status.