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Individual Differences in Behavioral Responses to Palatable Food or to Cholecystokinin Predict Subsequent Diet‐Induced Obesity
Author(s) -
Wald Hallie S.,
Grill Harvey J.
Publication year - 2019
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22459
Subject(s) - cholecystokinin , obesity , feeding behavior , medicine , endocrinology , food intake , eating behavior , food science , psychology , biology , receptor
Objective This study investigated whether individual differences in behavioral responses to palatable food and to the satiation signal cholecystokinin (CCK) in outbred chow‐maintained Sprague‐Dawley rats enabled prediction of individual differences in weight gained after subsequent high‐fat/high‐sugar diet (HFHSD) maintenance. Methods Meal size, meal number, and early dark cycle intake during initial HFHSD exposure were measured, as were early dark cycle sucrose solution and chow intake, chow meal size and meal number, the intake‐suppressive effects of 0.5‐µg/kg CCK injection, and CCK‐induced c‐Fos activation in the nucleus tractus solitarius. Subsequently, rats were maintained on an HFHSD for 5 weeks, and weight gain was determined. Results Rats that took larger and less frequent meals on the first day of HFHSD exposure, whose early dark cycle intake (HFHSD and sucrose) was larger during initial HFHSD exposure, gained more weight after HFHSD maintenance. Rats with lesser sucrose intake suppression in response to CCK gained more weight after HFHSD maintenance and displayed reduced CCK‐induced c‐Fos activation in the nucleus tractus solitarius. Conclusions Together, these data identify individual differences in behavioral responses to palatable food and to CCK as novel predictors of diet‐induced obesity.