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Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial
Author(s) -
Xiao Di,
Zhu Lanjun,
Edirisinghe Indika,
Fareed Jawed,
Brailovsky Yevgeniy,
BurtonFreeman Britt
Publication year - 2019
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22406
Subject(s) - postprandial , medicine , glycemic , prediabetes , crossover study , diabetes mellitus , meal , red meat , insulin , insulin resistance , randomized controlled trial , placebo , type 2 diabetes , endocrinology , pathology , alternative medicine
Objective This study investigated the effect of red raspberry intake on meal‐induced postprandial metabolic responses in individuals who have overweight or obesity with prediabetes and insulin resistance (PreDM‐IR), and in metabolically healthy individuals (Reference). Methods Thirty‐two adults (PreDM‐IR, n = 21; Reference, n = 11) were randomized to a controlled, three‐arm, single‐blinded, crossover trial. Participants were provided 0 g of frozen red raspberries (Control), 125 g of frozen red raspberries (RR‐125) (~1 cup), or 250 g of frozen red raspberries (RR‐250) (~2 cups), with a challenge breakfast meal (high carbohydrate/moderate fat) on three separate days. Multiple blood samples were collected up to 8 hours post breakfast with a final blood sample at 24 hours. A snack was provided at 6 hours. Results Breakfast containing RR‐125 and RR‐250 significantly reduced 2‐hour insulin area under the curve, and RR‐250 reduced peak insulin, peak glucose, and 2‐hour glucose AUC compared with Control in the PreDM‐IR group ( P < 0.05). Postprandial triglycerides were significantly lower after RR‐125 versus RR‐250 ( P = 0.01) but not different from Control ( P > 0.05). No significant meal‐related differences were observed for oxidative stress or inflammatory biomarkers. Conclusions Our findings suggest that red raspberries aid in postmeal glycemic control in individuals with PreDM‐IR, reducing glycemic burden with less insulin, which may be related to improved tissue insulin sensitivity.