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Transcriptional Control of Brown and Beige Fat Development and Function
Author(s) -
Shapira Suzanne N.,
Seale Patrick
Publication year - 2019
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22334
Subject(s) - adipose tissue , white adipose tissue , brown adipose tissue , energy homeostasis , endocrinology , medicine , function (biology) , biology , homeostasis , energy metabolism , energy expenditure , obesity , microbiology and biotechnology
Adipose tissue, once viewed as an inert organ of energy storage, is now appreciated to be a central node for the dynamic regulation of systemic metabolism. There are three general types of adipose tissue: white, brown, and brown‐in‐white or “beige” fat. All three types of adipose tissue communicate extensively with other organs in the body, including skin, liver, pancreas, muscle, and brain, to maintain energy homeostasis. When energy intake chronically exceeds energy expenditure, obesity and its comorbidities can develop. Thus, understanding the molecular mechanisms by which different types of adipose tissues develop and function could uncover new therapies for combating disorders of energy imbalance. In this review, the recent findings on the transcriptional and chromatin‐mediated regulation of brown and beige adipose tissue activity are highlighted.