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Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children
Author(s) -
Hollensted Mette,
Fogh Mette,
Schnurr Theresia M.,
Kloppenborg Julie T.,
Have Christian T.,
Ruest Haarmark Nielsen Tenna,
Rask Johanne,
Asp Vonsild Lund Morten,
FrithioffBøjsøe Christine,
Østergaard Johansen Mia,
Vincent Rosenbaum Appel Emil,
Mahendran Yuvaraj,
Grarup Niels,
Kadarmideen Haja N.,
Pedersen Oluf,
Holm JensChristian,
Hansen Torben
Publication year - 2018
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22308
Subject(s) - overweight , medicine , anthropometry , obesity , danish , childhood obesity , body mass index , population , demography , environmental health , philosophy , linguistics , sociology
Objective This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single‐nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents. Methods Children and adolescents with overweight or obesity ( n = 920) and a population‐based control sample ( n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention ( n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models. Results At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity ( β = 0.033 [SE = 0.01]; P = 0.001) and in the population‐based sample ( β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention. Conclusions A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.