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The Components of Age‐Dependent Effects of Dietary Methionine Restriction on Energy Balance in Rats
Author(s) -
Wanders Desiree,
Forney Laura A.,
Stone Kirsten P.,
Hasek Barbara E.,
Johnson William D.,
Gettys Thomas W.
Publication year - 2018
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22146
Subject(s) - weaning , energy balance , methionine , medicine , body weight , endocrinology , balance (ability) , energy expenditure , young adult , zoology , fat accumulation , biology , obesity , physical therapy , biochemistry , ecology , amino acid
Objective Dietary methionine restriction (MR) improves biomarkers of metabolic health, in part through coordinated increases in energy intake and energy expenditure (EE). Some metabolic benefits of dietary MR are secondary to its effects on energy balance, so this study's purpose was to examine how age at initiation of MR influences its effects on energy balance and body composition. Methods Energy balance was examined in rats provided control or MR diets for 9 months after weaning or in rats between 6 and 12 months of age. Results Rats provided the control diet for 9 months after weaning increased their body weight (BW) and fat mass by five‐ and eightfold, respectively, while BW and fat accumulation in the MR group were reduced to 50% of that of controls. In adult rats fed the respective diets between 6 and 12 months of age, dietary MR increased energy intake by ∼23%, but the 15% increase in EE was sufficient to prevent increases in BW or fat mass. Conclusions Dietary MR produces comparable increases in EE in young, growing animals and in mature animals, but young animals continue to deposit new tissue because of the proportionately larger effect of MR on energy intake relative to maintenance requirements.