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MiR‐27b‐3p Regulation in Browning of Human Visceral Adipose Related to Central Obesity
Author(s) -
Yu Jing,
Lv Yifan,
Di Wenjuan,
Liu Juan,
Kong Xiaocen,
Sheng Yunlu,
Huang Min,
Lv Shan,
Qi Hanmei,
Gao Mei,
Liang Hui,
Kim Sarah,
Fu Zan,
Zhou Hong,
Ding Guoxian
Publication year - 2018
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22104
Subject(s) - adipose tissue , browning , medicine , endocrinology , white adipose tissue , microrna , waist , obesity , human obesity , thermogenin , biology , gene , biochemistry
Objective Given the rising prevalence of central obesity and the discovery that beige cells appear within white adipose tissue, strategies to enhance these energy‐expending adipocytes or “browning” within white adipose depots have become of therapeutic interest to combat obesity and its associated disorders. This study focused on, the role of microRNA (miRNA)‐27b‐3p in human visceral adipose tissue (VAT) browning. Methods Expression of miR‐27b‐3p and UCP1 in VAT and serum of humans was measured. MiR‐27b‐3p was overexpressed or suppressed in human visceral stromal fraction cells to analyze the potential role of miR‐27b‐3p. Results UCP1 expression in human VAT decreased with elevated BMI and waist‐hip ratio, whereas expression of miR‐27b‐3p was found to correlate positively with BMI and waist‐hip ratio. High expression of miR‐27b‐3p was associated with reduced browning ability of human visceral adipocytes. Antagonism of miR‐27b‐3p led to the enhancement of browning ability in human visceral adipocytes. Conclusions These findings highlight the decreased browning ability of VAT from humans with obesity and the role of miR‐27b‐3p in regulating browning of human visceral adipocytes. They suggest that miR‐27b‐3p should be further explored as a potential target for the treatment of central obesity.