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Diastolic Blood Pressure Rises with the Exacerbation of Obstructive Sleep Apnea in Males
Author(s) -
Hu Wei,
Jin Xian,
Chen Chengjun,
Zhang Peng,
Li Dandan,
Su Qian,
Yin Guizhi,
Hang Yanwen
Publication year - 2017
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21960
Subject(s) - medicine , obstructive sleep apnea , blood pressure , cardiology , hypoxemia , body mass index , waist , exacerbation , endocrinology
Objective To characterize the association pattern between blood pressure (BP), metabolism changes, and obstructive sleep apnea (OSA) severity within male OSA patients. Methods The association between systolic BP (SBP), diastolic BP (DBP), glucose, lipids, apnea‐hypopnea index (AHI), oxygen desaturation index (ODI), and arousal index (ArI) was evaluated after adjustment for BMI and waist circumference/hip circumference ratio (WHR) in 1,370 male OSA patients. Results In the multiple linear regression models using SBP as an independent variable, SBP did not associate with the increase of any OSA indexes. BMI and glucose positively associated with AHI, ODI, and ArI elevation. WHR was also positively associated with increasing AHI and ODI. Total cholesterol levels increased with ODI and ArI increases. Triglyceride was associated with ArI. In the multiple linear regression models using DBP as an independent variable, DBP associated universally with AHI, ODI, and ArI with stable coefficients ranging from 0.19 to 0.20. The remaining independent variables were associated with AHI, ODI, and ArI with a similar trend to the models including SBP as an independent variable. Conclusions Apnea‐hypopnea, hypoxemia, and arousal changed glycometabolism, fat metabolism, and BP profoundly in a particular pattern.