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Metabolomic Determinants of Metabolic Risk in Mexican Adolescents
Author(s) -
Perng Wei,
Hector Emily C.,
Song Peter X.K.,
Tellez Rojo Martha Maria,
Raskind Sasha,
Kachman Maureen,
Cantoral Alejandra,
Burant Charles F.,
Peterson Karen E.
Publication year - 2017
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.21926
Subject(s) - metabolomics , metabolite , medicine , metabolome , metabolic syndrome , endocrinology , diabetes mellitus , physiology , biology , bioinformatics
Objective The goal of this study was to identify metabolites associated with metabolic risk, separately by sex, in Mexican adolescents. Methods Untargeted metabolomic profiling was carried out on fasting serum of 238 youth aged 8 to 14 years, and metabolites associated with a metabolic syndrome risk z ‐score (MetRisk z ‐score) were identified separately for boys and girls, using the simulation and extrapolation algorithm. Associations of each metabolite with MetRisk z ‐score were examined using linear regression models that accounted for maternal education, child's age, and pubertal status. Results Of the 938 features identified in metabolomics analysis, 7 named compounds (of 27 identified metabolites) were associated with MetRisk z ‐score in girls, and 3 named compounds (of 14 identified) were associated with MetRisk z ‐score in boys. In girls, diacylglycerol (DG) 16:0/16:0, 1,3‐dielaidin, myo‐inositol, and urate corresponded with higher MetRisk z ‐score, whereas N‐acetylglycine, thymine, and dodecenedioic acid were associated with lower MetRisk z ‐score. For example, each z ‐score increment in DG 16:0/16:0 corresponded with 0.60 (95% CI: 0.47‐0.74) units higher MetRisk z ‐score. In boys, positive associations of DG 16:0/16:0, tyrosine, and 5′‐methylthioadenosine with MetRisk z ‐score were found. Conclusions Metabolites on lipid, amino acid, and carbohydrate metabolism pathways are associated with metabolic risk in girls. Compounds on lipid and DNA pathways correspond with metabolic risk in boys.